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Duloxetine is an FDA-approved antidepressant. This medicine belongs to the class of antidepressants known as serotonin-noradrenaline reuptake inhibitors (SNRI). It is an oral medication mainly used to treat depression and anxiety disorder. It also treats the symptoms of diabetic nerve pain, fibromyalgia, and urinary incontinence in women.

Most patients suffering from depression and health conditions mentioned above find Duloxetine highly useful. However, it should only be used after consulting the doctor. This medicine is not for children below 18 years, pregnant women, or patients with serious health issues.

We strongly recommend getting a prescription & discovering if this medicine will suit your current health conditions or not.

Salt Composition: Duloxetine

Brand Names: Cymbalta & Yentreve

Prescription required: Yes


What is Duloxetine used for?

The following are the major uses of Duloxetine. We’re sharing the conditions in which Duloxetine soothes the patient:

  • Depression
  • Anxiety
  • Diabetic Nerve Pain
  • Fibromyalgia
  • Urinary Incontinence

How does Duloxetine work?

Duloxetine is an antidepressant that belongs to the SNRI class of drugs. It interacts with the brain chemicals & calms down the mind and body whenever depressive symptoms appear.

This medicine is highly effective as it interacts directly with the central nervous system. Whenever the patient feels anxious, depressive, or nerve pain, the neurotransmitters (chemical messengers) behave haphazardly. Here is when Duloxetine gets into action and signals the brain to calm down by boosting immune system’s response.

Dosage Instructions for Duloxetine

Duloxetine dosage may be prescribed differently depending on the medical conditions to be treated. For instance, it may be prescribed as one dose per day for anxiety and depression, while two doses per day might be prescribed too.

Consult your doctor & get a prescription to know the right dosage for you.

  • Duloxetine capsules should be used as a whole. Don’t crush, break, chew, or open the capsules.
  • Swallow Duloxetine capsules with a glass of water. Make sure you take Duloxetine at the same time daily for better effectiveness of the medicine.
  • Avoid overdosing Duloxetine in any condition.
  • Use Duloxetine with or without food. It is equally effective in both scenarios.

Side-effects of Duloxetine

The following side-effects can be observed in moderate to severe nature among the patients using Duloxetine:

  • Nausea
  • Headache
  • Dizziness
  • Drowsiness
  • Numbness
  • Dry Mouth
  • Mood Swings
  • Muscular Weakness
  • Constipation
  • Vomiting
  • Blurry Vision

Interactions with other Medicines

Duloxetine might not interact well with other medicines. Hence, it is important to tell your doctor if you’re using medicines like:

  • Tablets containing Duloxetine
  • Other antidepressants
  • Cannabis (Recreational Drugs)
  • Blood-thinning medicines (Eg: Warfarin)
  • Diazepam or Chlorphenamine
  • Thramadol

How does Duloxetine Make you Feel?

Duloxetine lifts up the mood. The patient feels less anxious and also improves the conditions of insomnia.

It may take some time for the body to adjust to Duloxetine. And so the patient might not see these effects for a couple of weeks, but when it starts working, it makes you feel better.

Storage Instructions

  • Store Duloxetine capsules between 15 to 25 Degrees Celsius
  • Keep Duloxetine out of reach of children

Important Information

  • Do not drink alcohol as long as you use Duloxetine as it may cause serious health impacts together.
  • Don’t use Duloxetine without prescription or for children under 18 years.
  • Avoid doing attention-seeking activities after Duloxetine as it makes you feel dizzy. Thus, accidents may occur.
  • Tell your doctor if you have severe health issues like cardiovascular problems, kidney and liver problems, eye problems like glaucoma, or anything similar.
  • Discuss your allergies and medicines that don’t suit you so that the doctor can prescribe a better antidepressant accordingly.


1) Is Duloxetine FDA approved?

Yes. Duloxetine is an FDA-approved antidepressant. It can be easily found at the local medical stores as well as available for online purchase.

2) How much Duloxetine should I use?

Only a doctor can prescribe the right dosage according to the symptoms you’re suffering from. Sometimes, you might be prescribed with one dosage per day, while sometimes you may have to take Duloxetine twice a day.

3) Who should not use Duloxetine?
  • Children under 18 years of age
  • Patients allergic to Duloxetine
  • Pregnant women, women planning to conceive or breastfeeding
  • Patients with Heart Problems, Kidney & Liver Problems, Eye Problems, and so on

There could be more conditions when Duloxetine is not suitable. Consult your medical practitioner for further guidance.

4) What happens if I miss or skip the dosage?

Don’t worry if you have missed or skipped any dosage of Duloxetine. You may continue with the next scheduled dosage.

5) What happens if I overdose on Duloxetine?

Overdosing Duloxetine will not increase its effectiveness. If you overdose Duloxetine, serious negative health impacts can appear. Hence, overdosing should be strictly avoided.

6) When will I see the effectiveness of Duloxetine?

It may take a couple of weeks for some patients, while it may take at least four weeks for some patients to feel the expected effects of this medicine. Depending on the symptoms you’re suffering from, it may take time to heal you.

7) Is Duloxetine addictive?
  • Duloxetine is not addictive. However, if you think you are using Duloxetine for too long now, you may consult the doctor. Ask them to guide you on how to stop taking medicine safely.
  • Let us tell you that you cannot stop taking Duloxetine suddenly.
  • You may see effectiveness and health improvements after a few weeks, but this does not mean you heal completely. Ask your doctor until when you should take Duloxetine.
8) Do I need to avoid any food or drink while using Duloxetine?

No. Duloxetine doesn’t have any negative interactions with particular food or drinks (except alcohol).